The Moon Stone Cannon is the most powerful weapon in the game, even surpassing the Harpoon Cannon.
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The Moon Stone Cannon is mounted aboard the prototype ship Delphinus, given to Vyse by Enrique. The cannon can kill most enemies with one shot and can be used to escape Valua for the second time. It appears as De Loco's 'Test Cannon' during the second ship battle with him above Ixa'Taka, although De Loco's cannon is just a prototype and not as powerful as the one Vyse eventually gains.